It is present in cells in two forms: reduced, known as GSH, and oxidized as GSSG (glutathione disulfide) (42)
Billings JL, Gordon SL, Rawling T, Doble PA, Bush AI, Adlard PA, Finkelstein DI, Hare DJ (2019) l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinsons disease
Stephen, B, Hajjar, J, Sarda, S, Duose, D, Conroy, J, Morrison, C, Alshawa, A, Xu, M, Zarifa, A, Patel, SP, Yuan, Y, Kwiatkowski, E, Wang, L , Rodon Ahnert, J, Fu, S, Meric-Bernstam, F, Lowman, G, Looney, TJ, Naing, A
PMID: 35413951
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Nrf2 binds to antioxidant response elements (ARE) and oxidative stress-related proteins (including GSH, HO-1, and oxidoreductase I), and then scavenges cytotoxic electrophiles together with ROS (218)