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Activation or suppression of these pathways results in enhanced bone resorption and impaired bone formation, ultimately disrupting skeletal homeostasis and leading to progressive bone loss ( 3.3 Mechanisms of OS driving OP 3.3.1 OS foundation OS characterized by the accumulation of oxidized substances in both intra- and extracellular environments, leads to an imbalance in redox homeostasis

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Additionally, MRI measurements at different pH levels showed significant differences in T1 values, correlating with the enhanced release of Gadobutrol in acidic conditions, typical of the tumor microenvironment

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2g and Extended Data Fig