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Stevia (natural sweetener)

Sirtuin-1 is the main deacetylase of PGC-1 ( PGC-1 could dock on NRF 1 and 2 to together drive the transcription and translation of the genes involving TCA cycle and OXPHOS systems, and then induce mitochondrial biogenesis

By controlling T cell metabolic pathways like glycolysis, OXPHOS, FAO, and amino acid metabolism, these tactics may effectively regulate T cell differentiation, function, and immune response, offering a fresh approach to the treatment of autoimmune diseases ( Figure 3 )

Shivakumar, S., Tsokos, G

Thushara RM, Gangadaran S, Solati Z, Moghadasian MH

(1979), pregnant sows were given PVC-resin formulations of dichlorvos (10%) in the diet at a daily dose of 0, 5, or 25 mg dichlorvos/kg body weight (divided between two doses per day) during the last one-third of pregnancy (or 30 days)