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These intra- and extracellular activities are involved in various aspects of APAP hepatotoxicity, and while they limit cellular stress responses, cause organelle damage, and mediate hepatocyte death, they are also involved in liver repair and regeneration ( 3 Diagnosis, screening, and prevention of AILI 3.1 Novel biomarkers In the past 50 years, the main serum biomarkers used to screen and monitor DILI include ALT (Figure 3)

The recovery of respiratory Complex I activity and membrane potential was significant after NAC treatment while that of ATP synthesis and activities of Complex IV and the matrix enzyme, aconitase was negligible in GSH-depleted cells

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Future intervention studies should use placebo-controlled designs with identical excipients to eliminate this bias