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Gundersen TD, Jrgensen N, Andersson AM, et al

Thats one reason some people notice effects more quickly than they do with oral supplements

3 patients had no-reflow at both timepoints, 1 patient showed resolution of no-reflow at TP2, 3 patients with subthreshold hypoperfusion at TP1 progressed to no-reflow at TP2 and 1 patient with normal perfusion at TP1 developed no-reflow at TP2

Treat the schedule above as reported use, not a recommendation

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However, studies to date have been limited by small sample sizes, varying treatment protocols, and frequent recurrences of SIBO, mainly due to gastrointestinal dysmotility that persists in SSc