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Elias R, Yan F, and Singla N, et al (2019) Immune-related adverse events are associated with improved outcomes in ICI-treated renal cell carcinoma patients J Clin Oncol 37 (7_suppl) 645 65

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When stored at 2 to 8 degrees Celsius (36 to 46 degrees Fahrenheit) , they remain potent until the printed expiration date, which is usually about 24 months from manufacture

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Most protocols call for morning dosing, though the evidence for timing specificity is thin