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Accordingly, the World Health Organization classifies G6PD-d based on the level of residual G6PD activity, with severe deficiency (Class I) causing chronic nonspherocytic hemolytic anemia and the least severe deficiency (Class IV) with little-to-no appreciable phenotype 8,11
With respect to the studied compounds, compound A (Ferrostatin) has been reported to show anti-ferroptotic activity inhibit neurotoxicity induced by glutamate in HT-22 mouse hippocampal cell culture [20]
Metabolism of homocysteine thiolactone in human cell cultures: possible mechanism for pathological consequences of elevated homocysteine levels
While these studies focus on cancer cells, they reveal that G6PD is an important negative regulator of cell intrinsic causes of ferroptosis
Together, these data indicate that antibody production and plasma cell differentiation are inversely related to G6PD activity