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[DOI] [PubMed] [Google Scholar] 401.Heijl A., Leske M.C., Bengtsson B., Hyman L., Bengtsson B., Hussein M

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Sirtuins, including SIRT3, play a central role by deacetylating key proteins in the electron transport chain, cyclophilin D of the mitochondrial permeability transition pore (MPTP), and antioxidant enzymes such as superoxide dismutase 2 (SOD2) [36, 37]

This theory implies that MFs can act as cellular messengers, eliciting physiological responses such as changes in cell survival, proliferation, apoptosis, differentiation, gene expression, protein synthesis, enzymatic activity, and ion homeostasis (Kashani et al., 2023

It counteracts muscle atrophy and promotes full functional recovery, as evidenced by improved biomechanical and functional assessments in treated rats