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In several murine transplantable models of cancer, MDSC were found to be the predominant source of prokineticin-2 (Bv8), a secreted protein involved in tissue-specific angiogenesis, which promoted vessel formation and tumor growth (87)

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Forni MF, Peloggia J, Braga TT, Chinchilla JEO, Shinohara J, Navas CA, Camara NOS, Kowaltowski AJ (2017) Caloric restriction promotes structural and metabolic changes in the skin

Physiol 309, F843F851

But its strength declines gradually after opening the vial