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statistical significance in f and h was determined by one-way ANOVA followed by Bonferroni post-hoc analysis

elucidated that sulforaphane restored the downregulation of SLC7A11/GSH, suppressed ferroptosis, and improved cardiac function by activating the AMPK/Nrf2 pathway in the myocardium of type 2 diabetic mice [48]

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A panel of lipid metabolism intermediates retrieved by ML also showed good performance in discriminating between bacterial and COVID-19 pneumonia [63]

Furthermore, the conjugated ADC must demonstrate high chemical stability in formulation, with minimal degradation or aggregation, which can be assessed by techniques such as size-exclusion chromatography (SEC) and sedimentation velocity analytical ultracentrifugation (SV-AUC) [41]

Finally, it will be necessary to perform integrative studies examining all aspects of GLUT4 traffic in appropriate model systems, to comprehensively chart its dysregulation in insulin resistance