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Maddalena G, Pellatt AJ, Eluri M, Parseghian CM, Aziz K, Alfaro K, Kell RJ, Bent AH, Huey RW, Uppal A, Konishi T, Overman MJ, Morelli MP, Willis J, YC Shen JP, Singh Raghav KP, Newhook TE, Morris VK, Dasari A, Kopetz S

Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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Gradogna et al

Tempra 66

Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)