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Journal of Investigative Dermatology, 2000, 115(6): 962-968

Published 2018 Jul 7

There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

The vial lasts long enough at these low doses that stability is never a concern within the 28-day window

I use it at night, a few times a week, and always wake up to skin that feels firmer and more even. If youre new to the ingredient or find your skin tends to flake and peel after using retinol, give this a try

Many researchers select peptide blends for long-term studies because they provide a consistent ratio of ingredients throughout the project