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Acknowledgments This work was supported by the competitive funding of Pirkanmaa hospital district (9E112 and 9D099) to R

On bone health: estrogen is one of the primary regulators of osteoclast activity

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The systemic effects of AKI that may contribute to mortality have been extensively investigated in preclinical models

These include methyl donors (such as DMG, TMG, betaine), fatty acids to help reduce inflammation (such as fish oil, flax seed), minerals (such as zinc, magnesium), herbs that support liver detoxification (such as milk thistle), vitamin C, and amino acids

Junnila RK, List EO, Berryman DE, Murrey JW, Kopchick JJ: The GH/IGF-1 axis in ageing and longevity