Long-term continuous use isnt generally recommended
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Specifically, rats with surgery alone exhibited mild stomach/duodenum lesions, considerable liver lesions, and severe cerebral/hippocampal lesions while those also administered diclofenac showed widespread severe lesions in the gastrointestinal tract, liver, cerebellar nuclear/Purkinje cells, and cere- brum/hippocampus
Through these combined effects on immune signaling, endocrine regulation, chemokine pathways, and mitochondrial function, shikonin demonstrates a multi-level mechanism of action in EMs