You don't need to kill yourself with exercise, but sitting on the couch while using AOD 9604 will produce modest results at best
Reconstitution AOD 9604 typically comes as lyophilized powder requiring reconstitution with bacteriostatic water
Theoretically, they operate through different mechanisms: semaglutide suppresses appetite and slows gastric emptying via GLP-1 receptors, while AOD 9604 acts on beta-3 adrenergic receptors on fat cells
In BAT, both lean and obese mice showed increased 3-AR expression following treatment, again paralleling reductions in BAT weight
The length of the infusion is also important
Best published PK (Awosemo et al., 2021, rats): ~38% oral bioavailability, ~6 to 7 hr oral half-life