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Given that ECs are at the lower end of the risk continuum [3,4,5,6] and are effective smoking cessation aids [7] among people who are actively trying to quit smoking in the near futureor alternatively, an appealing and lower-risk alternative consumer product for those who are not immediately planning to quit [8]ECs have the potential to substantially reduce smoking-attributable mortality in the population if they displace cigarette smoking, according to simulation modeling studies [9,10,11,12,13]