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In comparison to the control group, the LC group showed a slight improvement in SOD levels (5.23 11.97 vs

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Furthermore, melatonin combined with a ketogenic diet overcomes drug resistance to cisplatin and vincristine in BC-bearing mice by inducing apoptosis, inhibiting angiogenesis, lowering blood glucose, increasing ketone bodies, and downregulating resistance genes, achieving cure rates up to 70% 168

In vitro experiments using ALT-2074 revealed decreased inflammation in endothelial cells, suppressed oxidative damage, and prevented neuronal brain damage (Castagne and Clarke 2000)