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In 1998, Andrew Fire and Craig Mello reported that double-stranded RNA (dsRNA) had potent gene silencing effects in Caenorhabditis elegans , 38 a discovery they termed RNA interference (RNAi)

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They also reported that these patients had higher levels of interleukin 1 (IL-1), IL-6, and TNF- , suggesting an inflammatory state and oxidative stress in migraine patients (112)

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