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This subsequently led to a concentration-dependent inhibition of NE activation in U937 cells and dose-dependent inhibition of NE and PR3 activity (up to 97% and 99%, respectively) in BALF neutrophils in an in vivo LPS-challenge model in mice

Molecular analyses reveal that 5-amino-1MQ administration alters expression of key genes involved in epithelial-mesenchymal transition, including increased ZEB1 and SIRT1 expression alongside decreased TWIST and SERPIN1 levels

Frequency: Once daily (subcutaneous)

In: Gliski J, Horabik J, Lipiec J, editors

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