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So you mentioned breathing before, and oxygen is really important to humans, but one of the counterintuitive things that I learned from you is that carbon dioxide can actually be a good thing when it comes to healthy breathing

Cell 187 , 63586378.e6329 (2024)

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The use of antioxidants or immunosuppressant drugs to reduce ROS production is already widely used in clinical practice ( Origin of Oxidative Stress and Vulnerable Antioxidant System: Mechanistic Factors in Vitiligo Development It is well known in vitiligo patients that dramatic imbalance between the oxidant system (high) and EAS (deficient) leads to a predominant state of OS (Schallreuter, 2014)

The effects are concentration-dependent in ways that arent always linear, so skipping dose-response curves in your model is asking for trouble