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For larger cases, a part of the lesion and the surrounding healthy tissue can be taken for further laboratory analysis

Analyses include nicotine content, nicotine dissolution release, particle size, imaging (bulk filler and outer pouch material), bulk density (tapped and untapped), true density, crystallinity, solubility, oven volatiles (OV as measured by percent moisture content, % MC), pH of aqueous extracts, water activity, and extract viscosity

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For many smokers, it is tantamount to having an orgasm: the exhilaration of unwrapping a vacuum-sealed package of cigarettes, popping the foil, patting the pack against your arm, and then smelling the fresh tobacco

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