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Lyngfelt, M.C

This method can simultaneously capture common information among different modalities as well as unique information specific to each modality, thereby achieving a more comprehensive and interpretable representation of spatial multi-omics data

Transmission electron microscopy Cells were digested with 0.25% trypsin and 0.02% EDTA, washed with Hanks Balanced Salt Solution (HBSS)

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ROS, including H 2 O 2 , , and OH, damage DNA, proteins, and lipids, leading to aging and the etiology of many diseases

By sequencing the transcriptome of a single cell, it is possible to accurately capture changes in the expression of key resistance genes and reprogramming of signaling pathways within the cell, thereby revealing the molecular mechanism of gemcitabine resistance