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Many other factors can upregulate the expression level and activity of arginase, such as lipopolysaccharide, TNF-, glucose, thrombin, hypoxia and angiotensin II [reviewed in Pernow and Jung (2013)]

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6,7,8 The antioxidant effect of uric acid can be manifested in the inhibition of cell death to protect nerves as well as profile support of NO-mediated vasodilation