Application of 10 "]2 M Nel -AnglV and Dihexa in ballistically transfected hippocampal slices significantly increase spine densities (Figure 7) implying that such changes may in fact be occurring in the intact hippocampus
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whereas GIP enhances insulin secretion and affects fat metabolism and -cell proliferation (72, 73)
Given the arguable similarities between functional copper deficiencies evident in other neurodegenerative diseases, it is plausible that copper depletion is central node of neurodegeneration in general, only with different chemical/biological induction specific to each disease
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