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Aim to have 1.5-2 litres of fluids each day to stay hydrated

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A stable, cold environment is crucial

For each patient, the intensity of investigation depends on the patients age, severity of fecal incontinence, clinical assessment of risk factors and anal sphincter pressures, and response to previous therapy (Figure 21.6)

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Local inhibitory network GIPR-expressing neurons in the dorsal vagal complex (AP/NTS) are predominantly GABAergic with Gad1/Gad2 co-expression