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Major barriers to the clinical use of gene therapy, however, include transfection efficiency, the creation of long-term effects, the difficulty of controlling cell proliferation, ectopic transfection, disease transmission, patient-specific dose responses, immune reactions against viral proteins, possible side effects, and ethical issues [87, 88]

SURMOUNT-1 demonstrated this clearly when comparing tirzepatide results to historical semaglutide data

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Particular caution is required when using the drug There are no special precautions required