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Exposure of the bro-ALI model to non-nicotinized E-smoke from flavor-1 did not result in any detectable changes transcript level response whereas the corresponding nicotinized flavor resulted in a strong response as reflected by higher magnitude (fold change) and number of increased transcript levels of pro-inflammatory, oxidative stress, metalloproteinases, anti-proteases, alarm anti-proteases as well as microbial-defense markers

Yamada K, Takahashi H, Ohta A: Effects of 2,5-dimethylpyrazine on reproductive and accessory reproductive organs in female rats

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Q .2: Are e-cigarettes and vapes safe alternatives to smoking

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The sense of strength comes mainly from the blend and the figures printed on the pack: tar and nicotine yield