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Together, they have attracted attention as a tool for interrogating the coordinated regulation of pulsatile growth hormone (GH) secretion, downstream insulin-like growth factor 1 (IGF-1) synthesis, and related metabolic pathways

the dimer interface comprises a central region, the hinge region that is important for the proper dimer formation and orientation

Emerging evidence

High-quality, multicenter randomized controlled trials with standardized endpoints (e.g., proteinuria, eGFR slope), robust safety monitoring, and embedded mechanistic assessments are warranted

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