During preparation of this manucript, PUFA-containing plasmalogens were shown to promote ferroptosis [48], which complements our findings that alkyl chains strongly dictate sensitivity
Optical density values were determined at 450 nm using a microplate reader
Blevins, T
By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism
Additionally, we extended our focus to RIP1 and RIP3, which are key inducers of necroptosis in the early phase of APAP toxicity, manifesting effects within 2 h of administration (Liu et al
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