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Conceptually, co-targeting lactate handling (LDH/MCTs) together with chromatin writing (p300/CBP) may be rational in lactate-high tumors or therapy-induced lactate rebound contexts, but it should be framed as a strategy to re-shape lactate-driven transcriptional and microenvironmental states, supported by orthogonal pharmacodynamic readouts (for example, site-specific Kla quantified by mass spectrometry or rigorously validated antibodies)

In therapeutic doses, acetaminophen is detoxified by a combination of hepatic glucuronidation and sulfation and renal excretion

The only therapy for celiac disease is a lifelong gluten-free diet, which includes the avoidance of wheat, barley, and rye

10.1016/j.mad.2018.03.010 96 QuY.SunL.YangZ.HanR

By maintaining intracellular redox balance in contexts where oxidative stress is pathologically elevated