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Mouse hippocampal neurons stained by Nissl staining showed that the hippocampal neurons of mice in the Con, H1d, and H3d groups had an orderly arrangement but a disordered arrangement after prolonged hypoxia, especially in the H14d group

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Subsequent peer-reviewed preclinical studies have examined its use as a tool compound for investigating NNMT enzyme activity in adipose, liver, and skeletal muscle cell-based research models under controlled laboratory conditions