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Elevated levels of ferritin and transferrin, markers of iron dysregulation, have been observed in clinical ARDS cases, linking iron metabolism to disease severity ( Mitochondrial dysfunction exacerbates iron-driven ferroptosis by impairing the organelles ability to sequester and regulate iron levels

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The core components of the Wnt/-catenin signaling pathway include receptors FZD and LRP5/6, cytoplasmic transducers DvL, AXIN, APC, GSK-3, and CK-1, the key effector -catenin, and the transcription factor TCF/LEF (Foord et al., 2005

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As a dual board-certified pain management and anesthesiology physician, Dr