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Mechanistically, METTL3 and YTH N6-methyladenosine RNA binding protein 2 cooperatively modify PGC-1 mRNA, regulate PGC-1 degradation, and downregulate PGC-1 protein levels, thereby enhancing the inflammatory response

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In light of the prevalent challenges associated with peptide drugs, including their limited membrane permeability and instability in vivo , there is an imperative to explore the potential of nanotechnology, such as liposomes and polymer nanoparticles, for the encapsulation of these peptides

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The liposomal packaging eliminates this process and protects the active ingredient