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The absence of localization of CIPp-18 in lysosomes and no significant effect of metabolic energy inhibitors (2-DG or azide) which inhibit receptor-mediated endocytosis [61] suggested that the uptake of CIPp-18 is not mediated by endocytic process

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Given that the incident rate for repeated mTBI is 5.636% across the general population 15 , developing effective cognitive treatments remains an unmet need and critical gap in the field of traumatic brain injury 16

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