It will mainly be about understanding why the symptoms exist in the very first place, and why unless you address the root, they will keep backing you
No published time-course demonstrates diminishing effect, and mechanistic reviews note the absence of receptor desensitization that would predict tolerance
They have an injury secondary to inflammation or something like that
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Optimization and Characterization of Poly(Lactic-Co-Glycolic Acid) Nanoparticles Loaded with Astaxanthin and Evaluation of Anti-Photodamage Effect in Vitro
[DOI] [PubMed] [Google Scholar] 91.Lebeau P.F., Byun J.H., Platko K., Saliba P., Sguazzin M., MacDonald M.E., Par G., Steinberg G.R., Janssen L.J., Igdoura S.-A., et al