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Gillman, 2017b)
These changes have long been associated with depression ( However, depression in AD is more specifically linked to deficits in certain brain regions and AD-related pathological changes
Peripheral and cochlear mechanisms include N-methyl-D-aspartate receptor activation, 62 altered operating points of outer hair cells, 63 stereociliary detachment, 64 and elevated intracochlear potentials
However, because excessive copper exposure can be harmful, research protocols monitor total copper levels, especially in systemic studies
TRAEs of grade 3 or 4 included cytokine release syndrome (CRS), hypotension, cytopenia, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increase (Table 1)
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