Ethics statement The animal study was reviewed and approved by Kanazawa University Animal Experiment Committee
Vitamin B12 is found almost exclusively in animal-based products
Direct evidence of the importance of selenoproteins in mitigating oxidative stress was demonstrated in transgenic studies where overexpression of GPx4 significantly reduced lipid peroxidation in atherosclerosis and ischaemiareperfusion mouse models ( Reference Guo, Ran and Roberts 33 , Reference Dabkowski, Williamson and Hollander 34 )
(PubMed) Amagase H, Petesch BL, Matsuura H, Kasuga S, Itakura Y
doi: 10.3389/fcell.2026.1813085 Received 18 February 2026 Revised 27 March 2026 Accepted 06 April 2026 Published 29 April 2026 Volume 14 - 2026 Edited by Maja Jazvinak Jembrek, Rudjer Boskovic Institute, Croatia Reviewed by Yi Wu, Chinese Academy of Sciences (CAS), China Brindha Devi P., Vels Institute of Science Technology and Advanced Studies, India Updates Copyright 2026 Ye, Hong, Liu, Wang, Zhang, Zheng, Yu and Wang
These molecules were prioritized for their predicted binding affinity and potential inhibitory activity against acetylcholinesterase (AChE)