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The substrates and products of the DHODH reaction have opposite effects on ferroptosis, suggesting that the potential role of DHODH in regulating ferroptosis sensitivity is independent of its function of producing pyrimidine nucleotides
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N-Hcy-Lys, Cys, Hcy and GSH react quantitatively in plasma in the presence of a slightly alkaline buffer to give corresponding 2-pyridinium derivatives
This model allows full control over every step of the process in line with FDA-organic certification and GMP standards