As a lipidated amylin analogue, maintaining structural fidelity is particularly important because receptor binding and signaling activity depend on the peptide's engineered sequence modifications and lipidation profile [1]
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MS peptide assignment Five sets of 24 MS raw data files acquired from analysis of 24 fractions from each set are searched against the human protein sequences database obtained from the UniprotKB website using the Proteome Discoverer 2.4 software (Thermo, San Jose, CA) based on the SEQUEST and percolator algorithms
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Uncovering CNS access of lipidated exendin-4 analogues by quantitative whole-brain 3D light sheet imaging
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