It sustains adequate redox cell signaling since a physiologic level of oxidative stress is fundamental for controlling life processes via redox signaling, but excessive oxidation causes cell and tissue damage
The laboratory approached BOC Sciences because of our portfolio of cationic lipid technologies and our experience with "Ethosomes" (ethanol-containing vesicles) which are known for enhancing deep skin penetration
For example, in breast cancer cells, TQ upregulated peroxisome proliferator-activated receptor (PPAR-) while downregulating anti-apoptotic genes such as Bcl-2 and Bcl-xL , thus inducing programmed cell death
This process not only alleviates the oxidative stress of the wound, but more importantly, the O 2 produced, as a key substrate, greatly alleviates the hypoxic state of the wound bed, thereby significantly enhancing the SDT efficacy of the sonosensitized agent PCN-224 and enabling it to efficiently generate ROS to kill bacteria
N.SabatiniR.PurkallD
[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Kehrer J.P
