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In contrast, zinc-dependent class I histone deacetylases HDAC13 and the NAD-dependent sirtuins SIRT13 serve as the main lysine delactylases in cells, with SIRT3 standing out as a crucial mitochondrial eraser that also targets a subset of nuclear proteins

Gut 1978;19:1105-9

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Excessive ROS production can induce ferroptosis in ECs and inhibit expression of cell adhesion proteins, such as ZO-1, connexin 43 and VE-cadherin, thereby damaging inter-EC connections and increasing vascular permeability

2003, 167: A889-10.1164/rccm.200208-861OC

Regulatory status can change over time