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[DOI] [PubMed] [Google Scholar] 34.Rubino F.M., Pitton M., Brambilla G., Colombi A

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In a recent systematic review and meta-analysis of RCTs (2016), treatment with NADs compared to placebo or no intervention was associated with improvement in HE in 1/3 of patients (relative risk [RR]: 0.63, 95% confidence interval [CI]: 0.53-0.74, number needed to treat [NNT]: 4), and reduced mortality by half (RR: 0.49, 95% CI: 0.23-1.05, NNT: 100)

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Taken together with AC/FC reduction by HF treatments in this study, carnitine metabolic changes might be not only distinct prognostic biomarkers, but also be therapeutic targets for HF