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[16] Transport-mediated absorption and tissue delivery is a complex process involving three transport proteins: haptocorrin (HC), intrinsic factor (IF) and transcobalamin II (TC2), and respective membrane receptor proteins (Figure)

For example, if you look on Clinicaltrials.gov, there are only two studies that even mention BPC-157, says Cushman

Use a cold pack, not direct ice If your peptides need to stay cold, use an insulated bag with a cold pack rated for 28C, and avoid direct ice contact, which can freeze and damage them

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After 8 weeks of continuous hyperglycemia averaging ~500 mg/dL, the mice underwent the above fracture procedure