10.1021/bi0353979 17 BurrusC
of a cool beverage
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This auto-oxidation process generates toxic reactive oxygen species (ROS), quinones, and free radicals that damage intracellular organelles, deplete cellular glutathione, and ultimately trigger apoptotic cell death (Lohr et al., 2014
However, in sub-healthy conditions such as SCD, there is significant retention of mitochondria, large amounts of heme iron and molecular oxygen in red blood cells, which are therefore susceptible to ferroptosis stress
It is particularly prevalent among women in their 40s and 50s because the transition into menopause involves a significant decline in estrogen
