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Bivariate sensitivity analysis provides a valuable approach to evaluating riskbenefit trade-offs by simultaneously varying two variables and assessing their combined impact on population-level outcomes

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A prior study with a small sample size showed that smokers homozygous for the CYP2A6 deletion (and therefore having impaired enzyme function) showed lower cumulated urinary cotinine excretion compared to individuals who were homozygous CYP2A6*1 (Kitagawa et al., 1999)

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