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human evidence is thin but real PL-14736 (its clinical-development name) reached abstract-level Phase 1/2 in ulcerative colitis, a modern hamstring tendon Phase 2 RCT is recruiting, and an intra-articular knee case series exists

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Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, OReilly LA, Callus BA, Lopez A, Strasser A et al (2009) Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim