These pathogenic factors act as the major driving force to promote renal injuries towards fibrosis (Gu et al., 2020b), which may eventually lead to chronic kidney disease (CKD) or end-stage renal disease (ESRD)
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This process is vital for tissues like tendons, which naturally have a poor blood supply
Binding specificity and mechanistic insight into glutaredoxin-catalyzed protein disulfide reduction
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Finally, the gut microbiome may contribute to NAFLD pathogenesis: an increased intestinal permeability could lead to the entry of endotoxins in portal circulation and activation, through toll-like receptor 4, of Kupffer cells, with consequent inflammation (5053)
