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High quantities of reactive oxygen species (ROS) cause oxidative stress due to an imbalance between intracellular oxygen production and the body's antioxidant system

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Apoptosis of uterine leiomyoma cells was also stimulated by the expression of caspase-3, an important mediator for apoptosis, and by caspase-9, an initiator of apoptosis (Malik et al., 2009)

Implicated cytokines include TNF-, IL-1, IL-6 & complement immune complexes

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