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Senescent cells build up with age and secrete pro-swelling cytokines, proteases, and growth factors collectively known as the senescence-linked secretory phenotype (SASP)

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We can't stress this enough: the storage guidelines for an unopened vial and an opened vial are completely different

Over many years, symptoms can worsen to the point of severe disability, necessitating placement in a skilled nursing facility (especially with the development of dementia or frequent falling)